Mikayel Mirzoyan was born in Tbilisi. In 1908, he graduated from the Nersisyan School. Mikayel continued his education at the Tbilisi Music College and later at the Tbilisi Conservatory, graduating in 1921 from the class of Nikolai Cherepnin. From 1928 to 1958, he worked as the head of the academic department at the Alexander Spendiaryan Music School in Yerevan. Mirzoyan primarily composed chamber music, children's songs, choral works, marches, and romances, as well as an epic ballad. In 1966, a collection of his songs and romances, edited by Robert Atayan and M. Mirzoyan, was published in Yerevan. In 1939, he was honored with the title of Honored Art Worker of the Armenian SSR. He was also awarded the "Order of the Badge of Honour." Mikayel Mirzoyan passed away in Yerevan.