Ruben Grigoryan was born in Tiflis. He studied at Tehran Conservatory (violin class), Paris Music College - Arthur Honegger class of composition. From 1946 to 1951 taught at the Tehran Conservatory, was the conductor and the director of conservatory from 1948 to 1951. Since 1952 lived in Boston. Ruben Grigoryan founded Komitas Quartet, from 1955 directed "Choral Society named after Komitas, from 1952 organized and directed concerts of Armenian symphonic music and performed works by Armenian composers. He is an author of symphonic poems, suites, symphony, operetta and string quartets. Ruben Grigoryan arranged Armenian medieval and folk songs, in 1970 and 1972 performed in Yerevan. Ruben Grigoryan died in Boston (USA).