Samvel Ghazaryan worked at Sundukyan State Academic Theatre, then at Theatre of Young Spectator, at Alexander Shirvanzade Drama Theatre of Kapan and Artashat State Drama Theatre. Ghazaryan played about 70 roles. Along with positive heroes, he also played negative roles. Performances on different stages were a school of life, art and culture for the actor. He was awarded with Gold medal of Ministry of Culture of Armenia.