He was born in Goris (Syunik Province, Armenia). In 1934 he graduated from the Goris Pedagogical College, and in 1934–1941 he worked as a teacher. He took part in the Great Patriotic War (1941–1945). His first short story was published in 1934 in the Goris newspaper "Karmir Zangezur" (Red Zangezur). Sero Khanzadyan received a number of state awards. He died in Yerevan and is buried in the Pantheon of Komitas Park.
